Arts and entertainment

• Chuck Alaimo, American saxophonist, leader of the Chuck Alaimo Quartet
• Chuck Barris (1929–2017), American TV producer
• Chuck Berry (1926–2017), American rock and roll musician
• Chuck Brown (1936–2012), American guitarist and singer
• Chuck Close (1940–2021), American painter and photographer
• Chuck Comeau (born 1979), Canadian drummer
• Chuck Connors (1921–1992), American athlete and actor
• Chuck D (born 1960), stage name of Carlton Douglas Ridenhour, American rapper
• Chuck Garric, rock bassist of Alice Cooper
• Charlton Heston, "Chuck", (1923–2008), American actor and political activist
• Chuck Holmes (entrepreneur) (1945–2000), American entrepreneur and philanthropist, founded Falcon Studios
• Chuck Jones (1912–2002), American animator, screenwriter, producer, and director of animated films
• Chuck Leavell (born 1952), American pianist and keyboardist
• Chuck Lorre (born 1952), American television writer, director, producer, composer, and production manager
• Chuck Mangione (born 1940), American flugelhorn player and composer
• Chuck Norris (born 1940), American martial artist, actor and media personality
• Chuck Palahniuk (born 1962), American novelist and freelance journalist
• Chuck Schuldiner (1967–2001), American singer, songwriter, and guitarist
• Chuck Traynor (1937–2002), American pornographer
• Charles F. Walker, American historian
• Chuck Willis (1928–58), American blues singer and songwriter
• Chuck Woolery (born 1941), American actor, singer and game show host

Sports

• Chuck Bennett (1907–1973), American football player and coach
• Chuck Carney (1900–1984), American football and basketball player
• Chuck Clark (born 1995), American football player
• Chuck Clements (born 1973), American football player
• Chuck Cooper (basketball), (1926–1984), American basketball player
• Chuck Detwiler (born 1947), American football player
• Chuck Dressen (1898–1966), an American third baseman, manager and coach in professional baseball
• Chuck Drulis (1918–1972), American football player and coach
• Chuck Ealey (born 1950), American Canadian football player
• Chuck Fusina (born 1957), American college and professional football player
• Chuck Gelatka (1914–2001), American football player
• Chuck Hulse (1927–2020), American racing driver
• Chuck Hutchison (born 1948), American football player
• Chuck Lanza (born 1964), American football player
• Chuck Liddell (born 1969), American mixed martial artist and former UFC champion
• Chuck Long (born 1963), American football coach
• Chuck McKinley (1941–1986), American men's amateur tennis player
• Chuck Noll (1932–2014), American football coach
• Chuck Osborne (American football) (1973–2012), American football player
• Chuck Taylor (American football), American football player and coach
• Chuck Taylor (salesman) (1901–1969), American basketball player and shoe salesman/evangelist
• Chuck Taylor (baseball) (1942–2018), American baseball pitcher and player
• Chuck Wepner (born 1939), American heavyweight boxer
• Chuck Weatherspoon (born 1968), American football player

Politics

• Chuck Fager (born 1942), American activist, author, editor, publisher, and prominent member of the Religious Society of Friends
• Chuck Grassley (born 1933), senior United States senator from Iowa, serving since 1981
• Chuck Hagel (born 1946), United States Secretary of Defense, February 27, 2013 to February 13, 2015
• Chuck Schumer (born 1950), politician, and senior United States senator from New York, serving since 1999

Other

• Chuck Hull (born 1939), inventor of 3D printing
• Chuck Testa (born 1956), American taxidermist
• Chuck Yeager (1923–2020), retired brigadier general in the United States Air Force and record-setting test pilot
• Charles W. Mooney Jr., American, the Charles A. Heimbold, Jr. Professor of Law, and former interim Dean, at the University of Pennsylvania Law School

• Chuck, a character in the 1985 American adventure comedy film Pee-wee's Big Adventure
• Chuck Anderson, a character in the 2023 British comic book limited series Nemesis Reloaded
• Chuck Armstrong, a dark blue anthropomorphic car in the Pixar animated film Cars
• Chuck Billy (Chuck Billy 'n' Folks), a character from Monica's Gang and Chuck Billy 'n' Folks
• Chuck E. Cheese, Anthropomorphic restaurant mascot
• Chuck Bartowski, main character of the American television show Chuck
• Chuck (Pokémon), a character in the Pokémon universe
• Chuck, a character from Kodomo no Jikan, a Japanese manga series
• Chuck, a character from Panty & Stocking with Garterbelt, a Japanese anime television series
• Chuck, an anthropomorphic dump truck in the preschool TV series The Adventures of Chuck and Friends
• Chuck Greene, protagonist of Dead Rising 2
• Chuck (Stargate), a character from the Stargate television series
• Charlotte "Chuck" Charles, a character from the television series Pushing Daisies
• Chuck Bass, a character from the television series Gossip Girl
• Chuck, a male, triangular-shaped yellow canary in the Angry Birds games
• Chuck Cunningham, a character from the sitcom Happy Days
• Chuck Chambers, a character from iCarly
• Chuck McCoy, a character from Austin & Ally
• Chuck McGill, a character from the American television series Better Call Saul
• Chuck Miller, a character in the American teen romantic comedy 1987 movie Can't Buy Me Love
• Chuck Pearson, a character in 1989 American independent coming of age comedy movie She's Out of Control
• Chuck Rhoades, a character from the American television series Billions
• Polly Chuck, a character in the anime television series Fables of the Green Forest
• Not Chuck, a character referred to as 'Chuck' by Lightning McQueen in Cars